(Re)inventing the Circadian Feedback Loop

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The BMAL1 C terminus regulates the circadian transcription feedback loop.

The circadian clock is driven by cell-autonomous transcription/translation feedback loops. The BMAL1 transcription factor is an indispensable component of the positive arm of this molecular oscillator in mammals. Here, we present a molecular genetic screening assay for mutant circadian clock proteins that is based on real-time circadian rhythm monitoring in cultured fibroblasts. By using this a...

متن کامل

The Arabidopsis circadian clock incorporates a cADPR-based feedback loop.

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signalin...

متن کامل

How does it work? A generic feedback loop circadian oscillator

Within the past 18 months, common regulatory patterns have emerged among eukaryotic circadian systems — extending from fungi through to mammals. Heterodimeric complexes of PAS-domain-containing transcription factors play positive roles in clock-associated feedback loops, and classic clock proteins like FREQUENCY (FRQ), PERIOD (PER), and TIMELESS (TIM) appear as negative elements. Post-transcrip...

متن کامل

Reinventing Computing Feedback - Directed Specialization of C

ion is a powerful tool for managing program complexity. Well-abstracted source code is far more comprehensible, maintainable, and reusable than less abstract, specialized code. In addition, because a single general routine may be called from several places within a program, a well-abstracted program is usually smaller than a more specialized one. Unfortunately, with traditional compiler technol...

متن کامل

The Per2 Negative Feedback Loop Sets the Period in the Mammalian Circadian Clock Mechanism

Processes that repeat in time, such as the cell cycle, the circadian rhythm, and seasonal variations, are prevalent in biology. Mathematical models can represent our knowledge of the underlying mechanisms, and numerical methods can then facilitate analysis, which forms the foundation for a more integrated understanding as well as for design and intervention. Here, the intracellular molecular ne...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Developmental Cell

سال: 2012

ISSN: 1534-5807

DOI: 10.1016/j.devcel.2012.02.007